Proopiomelanocortin (POMC) is the precursor of the melanocortin peptides alpha, beta and gamma. POMC neurons in the arcuate nucleus of the hypothalamus function as key central regulators of food intake and homeostatic control of energy balance in both rodents and non-human primates.
||See product label
||A synthetic peptide (YVMGHFRWDRFG) corresponding to the amino acids 77-88 from human Proopiomelanocortin (POMC). POMC is the precursor of the melanocortin peptides alpha, beta and gamma. The synthetic peptide was conjugated to carrier protein to enhance the immunological response.
||Gamma-melanocyte stimulating hormone; Melanotropin gamma; Corticotropin-lipotropin [Precursor]; Pro-opiomelanocortin; POMC
||IHC. A concentration of 1 in 2000 is recommended for IHC. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Specificity was demonstrated by immunohistochemistry.
||This antiserum is known to react with sheep. Other species have not yet been tested.
||If you would like to use this product in another species other than those specified here, or to see the shared identity between the immunogen used here in different species and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it.
||Reconstitute in 50µl sterile water. Centrifuge to remove any insoluble material.
||It is recommended that a thawed sample is stored at 4ºC for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20ºC or lower. Glycerol (1:1) can be added to neat serum for additional stability if intended use does not prevent this.
||12 months upon reconstitution
||Grayson BE, Allen SE, Billes SK, Williams SM, Smith MS, Grove KL (2006). Prenatal development of hypothalamic neuropeptide systems in the nonhuman primate.
J Neuroscience. 143(4) pp. 975-86.