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Receptor Body Chimeras

Fc-based fusion proteins, or Fc-Chimeras, are composed of an immunoglobin Fc domain that is directly linked to another peptide such as a ligand that activates upon interaction with a cell-surface receptor, a peptidic antigen (Ag) against a challenging pathogen or a ‘bait’ protein to identify binding partners assembled in a protein microarray. The Fc-domain hybrid endows the resulting chimera protein with additional powers not available before. Fc-chimeras have increased half-life; often offer an increase in solubility and stability to the protein partner, and provide a direct link to intracellular delivery via interaction with cellular Fc receptors. Also Fc-chimeras often dimerize via the Fc Ig domains and demonstrate an increased avidity as well a potency compared to the non-chimeric protein partner.

Biosensis is pleased to offer an increasing number of Fc-fusion receptor chimera proteins for neuroscience research. Our human cell expressed neurotrophin receptor chimeras include TrkA, TrKB, and p75NTR, as well as TrkC and important stem cell and adhesion molecules such as L-selectin and SCF

 Product Name+ 
 
 Catalogue No. 
 
 Price* 
 
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Human Epidermal Growth Factor Receptor-Fc Chimera expressed in mammalian cells   PE-1240-25   $217.00USD 
Human L-selectin-Fc Chimera expressed in mammalian cells   PE-1247-10   $127.00USD 
Human L-selectin-Fc Chimera expressed in mammalian cells   PE-1247-50   $357.00USD 
Human L-selectin-Fc Chimera expressed in mammalian cells   PE-1247-25   $217.00USD 
Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells   PE-1237-15   $187.00USD 
Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells   PE-1237-25   $217.00USD 
Human Nerve Growth Factor Receptor-Fc Chimera (222 amino acids) expressed in mammalian cells   PE-1238-25   $217.00USD 
Human Stem Cell Factor Receptor-Fc Chimera expressed in mammalian cells   PE-1244-50   $387.00USD 
Human TrkA-Fc Chimera expressed in mammalian cells   PE-1248-100   $357.00USD 
Human TrkA-Fc Chimera expressed in mammalian cells   PE-1248-50   $217.00USD 
Human TrkB-Fc Chimera expressed in mammalian cells   PE-1235-10   $127.00USD 
Human TrkB-Fc Chimera expressed in mammalian cells   PE-1235-20   $197.00USD 
Human TrkC-Fc Chimera expressed in mammalian cells   PE-1236-50   $297.00USD 
Mouse p75NTR Nerve Growth Factor Receptor-Fc Chimera expressed in mammalian cells   PE-1704-25   $217.00USD 
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