| Catalogue No. |
M-872-100 |
| Description |
AP2-beta is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes during early development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes. AP2-beta appears to be required for normal face and limb development and for proper termnal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. It can form homodimers or heterodimers with other AP-2 family members. Defects in AP2-beta are the cause of Char syndrome (CHAR) which is characterised by patent ductus anteriosus (PDA), facial dysmorphism and hand anomalies. |
| Batch No. |
See product label |
| Unit size |
100 µg |
| Antigen |
Recombinant human AP2-beta (amino acids 12-460) with GST tag. |
| Clone |
3G5-1D11 |
| Other Names |
Transcription factor AP2-beta; Activating enhancer-binding protein 2 beta; TFAP2B |
| Accession |
AP2B_HUMAN |
| Produced in |
Mouse |
| Purity |
Protein G purified immunoglobulin |
| Applications |
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. |
| Specificity |
Specificity has been confirmed by WB and direct ELISA against the antigen. |
| Cross-reactivity |
Human. Other species have not been tested. |
| Blast it |
To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it. |
| Form |
Lyophilised from PBS pH 7.2 |
| Reconstitution |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
After reconstitution keep aliquots at -20ºC for higher stability or at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles. |
| Expiry Date |
12 months after purchase |
