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Mouse monoclonal antibody to human Sodium channel protein type 8 subunit alpha [4G7]: IgG

$297.00USD


Catalogue No. M-864-100
Description
Sodium channel protein type 8 subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes. Adopting opened or closed conformation in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na ions may pass in accordance with their electrochemical gradient. It is a multi-pass transmembrane protein that is widely expressed in neurons of the central and peripheral nervous system. There are four named isoforms. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment, S4.  Segments S4 are thought to be the voltage-sensors and are characterised by a series of positively charged amino acids at every third position.
Batch No. See product label
Unit size 100 g
Antigen Partial recombinant human Sodium channel protein type 8 subunit alpha (amino acids 1854-1951) with a GST tag.
Clone 4G7
Other Names Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED
Accession SCN8A_HUMAN
Produced in Mouse
Purity Protein G purified immunoglobulin
Applications This antibody is recommended for WB, immunofluorescence and direct ELISA. The recommended dilution for this antibody is 10 g/ml for immunofluorescence. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity Specificity has been confirmed by WB and direct ELISA against the antigen.
Cross-reactivity Human, mouse and rat. Other species have not been tested.
Blast it To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it.
Form Lyophilised from PBS pH 7.2
Reconstitution Reconstitute in 100 l of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for higher stability or at 4C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
Images (click to zoom)
Mouse monoclonal antibody to human Sodium channel protein type 8 subunit alpha [4G7]: IgG
Immunofluorescent detection of Sodium channel protein type 8 subunit alpha expression in mouse NIH/ Swiss embryo cell lysate. The anti-Sodium channel protein type 8 subunit alpha primary antibody, catalogue number M-864-100, was used at a concentration of 10 µg/ml.

PDF Data Sheet

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MSDS

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