| Catalogue No.: |
M-802-100 |
| Batch No.: |
See product label |
| Unit size: |
100 µg |
| Antigen: |
Partial recombinant protein of human TPP1 (amino acids 195 to 305) with a GST tag. |
| Other Names: |
Tripeptidyl-peptidase 1, TPP-l, Tripeptidyl aminopeptidase, Lysosomal pepstatin-insensitive protease, LPIC, Cell growth-inhibiting gene 1 protein, GENE NAME: TPP1, CLN2 |
| Accession: |
TPP1_HUMAN |
| Description: |
TPP1 is a lysosomal serine protease with tripeptidyl-peptidase I activity. It may act as a non-specific lysosomal peptidase which releases an N-terminal tripeptide from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. TPP1 is detected in lysosomes and melanosomes in all tissues but it is highest in the heart and placenta. TPP1 is activated by autocatalytic proteolytic processing upon acidification within lysosomes. Defects in TPP1 cause classical late-infantile neuronal ceroid lipofuscinosis (LINCL) which is also known as ceroid lipofuscinosis 2 (CLN2). It is a fatal childhood neurodegenerative disease characterised by progressive visual and mental deterioration, motor disturbance, epilepsy and behavioural changes. |
| Produced in: |
Mouse |
| Purity: |
Protein G purified immunoglobulin |
| Applications: |
This antibody is recommended for direct and sandwhich ELISA, IHC and WB. |
| Specificity: |
The specificity of this antibody was confirmed by WB and ELISA against the immunogen. |
| Cross-reactivity: |
Human. Other species have not been tested. |
| Blast it: |
To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it. |
| Form: |
Lyophilised mouse IgG in phosphate buffered saline, pH7.6 |
| Reconstitution: |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage: |
After reconstitution keep aliquots at -20ºC for higher stability or at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles. |
| Expiry Date: |
12 months after purchase |
