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ProNGF / p75NTR, and Improved Bladder Function after Spinal Cord


A recent study* used the Biosensis proNGF RapidTM ELISA kit to demonstrate acute increase in proNGF in urine after spinal cord injury in mice (cat# BEK-2236) and humans (cat# BEK-2226). Treatment with an inhibitor of the proNGF-p75NTR interaction showed promise for improved bladder function.

* from the SO Yoon laboratory, Ohio State University (Ryu et al, JCI, 2018)

ELISA (left) and Western Blot (right) analysis of proNGF showing rapid increase sustained for 3 days post injury. Ryu et al, JCI 2018. Courtesy of Journal of Clinical Investigation.
Biosensis RapidTM ELISA kits for proNGF and p75-ECD provide the most sensitive kits available in a Ready-to-Use format. Results before LUNCH!