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A Quality Proven Orexin A Antibody for Neuroscience Research


In 1998, two research groups independently discovered Hypocretin (de Lecea et al) and Orexins (Sakurai et al) that are essentially the same neuropeptides (reviewed in Peyron & Kilduff, 2017). Hypocretin producing cell bodies are exclusively located in hypothalamus with extensive axonal projections within the central nervous system. The receptors for neuropeptides Orexin A and Orexin B (also known a hypocretin 1 and hypocretin 2, respectively) are G protein coupled receptors. The neuropeptides have been extensively studied in relation to sleep/wake cycle regulation linking to sleep disorder narcolepsy. However, the Orexin/Hypocretin system also plays important roles in several other physiological processes like feeding, addiction, reward and motivation, anxiety and depression, cardiovascular regulation, pain, migraine and neuroendocrine regulation.

Biosensis Rabbit antibody to Orexin A (14-33):
Catalog No# R-104-100 is an antisera against a synthetic peptide CRLYELLHGAGNHAAGILTL specific to bovine Orexin A.

Specificity of the antiserum is tested on rat brain. Based on sequence similarity it is expected to cross-react with mouse, human and numerous other species.

Validated by Experts and Published by Leading Laboratories

This is a superb antiserum for immunohistochemistry on Orexin A containing neurons exhibiting intense labelling of neurons with very low background.
  1. Kruger J.L. et al (2010) Cellular location and major terminal networks of the orexinergic system in the brains of five microchiropteran species. J Chem Neuroanat. 2010 Nov;40(3):256-62.
  2. Gaykema R.P. et al (2009) Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: their potential role in sickness behavior. Brain Behav Immun. 2009 Oct;23(7):926-30.
  3. Lee H.S. et al (2005) Retrograde study of hypocretin-1 (orexin-A) projections to subdivisions of the dorsal raphe nucleus in the rat. Brain Res. 2005 Oct 12;1059(1):35-45.
  4. Yao S.T. et al (2005) Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat. J Comp Neurol. 2005 Sep 19;490(2):180-93.

Other Orexin-Related Research Reagents from Biosensis 

Target Host Purity Reactivity Applications Clone Cat #
Orexin A (1-13) Chicken AP Hu, Ms, Rat ELISA   C-1531-100
Orexin B (1-14) Chicken AP Hu, Ms, Rat ELISA   C-1532-100
Orexin Receptor
Type 1 (327-342)
Rabbit AP Hu, Rat WB, ICH   R-1030-100
Orexin Receptor
Type 1 (327-342)
Mouse IgG Hu WB, ELISA 1E3 M-840-100