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Toxic Aβ25-35 Peptide Compromises Blood-Brain-Barrier Int


07/29/2019


Dear Researcher,
 
A recent study conducted by Cuevas E et al., 2019 investigated the toxicity of Aβ25-35 peptide in a rat Blood-Brain-Barrier (BBB) model. A comprehensive number of cellular and biochemical assays demonstrated that BBB dysfunction may contribute to AD pathology, involving the receptor for advanced glycation end products (RAGE). Aβ-immunoreactivity in rat brain microvascular endothelial cells (rBMVECs) was detected using Biosensis’ Aβ antibody clone MOAB-2 (6C3).


Figure a: Aβ25-35 – induced morphological changes of rBMVECs. Figure b: Analysis of RAGE (green) and Aβ (red) expression in an in vitro rat BBB model by fluorescent microscopy. Co-localization is seen as yellow color. Courtesy of Cuevas E et al., 2019.

Antibody clone MOAB-2 (6C3) is a pan-specific Aβ1-40/42 peptide antibody which does not cross-react with APP. Its suitability for Western Blotting, Immunohistochemistry, Immunofluorescence and Immunoprecipitation is backed up by a growing number of quality publications. Find out more here.

Did you know that many other companies sell the exact same Aβ antibody clone like Biosensis, but at increased cost to you?

 

Biosensis

Competitor 1

Competitor 2

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Amount

100 μg

100 μg

100 μg

100 μg

Price

US$ 297

US$ 429

US$ 377

US$ 330


Why pay more? Get publication-worthy data at a fair price! We maintain warehouses in the USA and Australia for prompt delivery of MOAB-2 (Clone 6C3) antibody. Email, phone or fax in your order (1-800-605-5127 USA/Canada or +61 8 8352 7711 rest of world) or buy online.

Good luck with your research,

The Biosensis Team
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