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Alpha synuclein control peptide (116-131)

$67.00USD


Catalogue No. PE-1606-100
Description Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Batch No. See product label
Unit size 100 g
Antigen A synthetic peptide (CMPVDPDNEAYEMPSEE) of human alpha synuclein protein (aa: 116-131).
Other Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Accession P37840 SYUA_HUMAN;
Purity Crude
Applications Control Peptide. This peptide may be used to block the binding activity of antibodies to alpha synuclein ( see Biosensis antibodies S-024-100 and S-075-50).
Blast URL Click here
Form Lyophilized
Reconstitution This peptide is soluble in PBS and water.
Storage After reconstitution keep at -20C. Avoid repetitive freeze/thaw cycles.
Expiry Date 24 months after purchase
PDF Data Sheet

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MSDS

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