Human Noggin protein expressed in mammalian cells

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Catalogue No.	PE-1245-5
Description	Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), of multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2).
Batch No.	See product label
Unit size	5 ug
Other Names	Nog;
Accession	Q13253 NOGG_HUMAN;
Produced in	Human - A DNA sequence encoding human Noggin protein (containing the signal peptide sequence and the mature human noggin sequence) was expressed in modified human 293 cells.
Molecular Weight	Human Noggin protein migrates as a band between 25 and 30 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. The unmodified Noggin has a predicted molecular mass of 23.0 kDa. Noggin separates into a number of isoforms with a pI between 4.2 and 5.3 in 2D PAGE due to post-translational modifications. The unmodified protein has a predicted pI of 9.1.
Purity	>95% as determined by SDS-PAGE and visualized by silver stain.
Form	The Noggin product consists of 5-25% carbohydrate by weight.
Reconstitution	It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial.
Storage	Lyophilized products should be stored at 2-8C. Following reconstitution, short-term storage at 2-8C is recommended and longer-term storage of aliquots at -18 to -20C. Repeated freeze/thawing is not recommended.

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