Neurofilaments contain three intermediate filament proteins: L, M and H, which are involved in the maintenance of the neuronal caliber. NF-H has an important function in mature axons. NF-H is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Defects in NF-H are a cause of amyotrophic lateral sclerosis (ALS) which is a neurodegenerative disorder affecting upper and lower motor neurons and results in fatal paralysis.
||See product label
||Partial recombinant human NF-H protein (263-364) with a GST tag.
||Neurofilament heavy polypeptide; Neurofilament triplet H protein; 200 kDa neurofilament protein; NEFH; KIAA0845; NFH
||Protein G purified immunoglobulin
||This antibody is recommended for WB and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Specificity has been confirmed by WB and direct ELISA against the antigen.
||Human. Other species have not been tested.
||To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it.
||Lyophilised from PBS pH 7.2
||Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
||After reconstitution keep aliquots at -20ºC for higher stability or at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
||12 months after purchase