Protein kinase minibrain homolog phosphorylates serine, threonine and tyrosine residues in its sequence as well as in exogenous substrates. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. There are 5 named isoforms produced by alternative splicing. It is expressed ubiquitously with highest levels in skeletal muscle, testis, fetal lung and kidney, and in the developing central nervous system. It localises to the nucleus speckle. This protein is overexpressed 1.5-fold in fetal Down syndrome brain and considered a strong candidate for learning defects associated with Down syndrome. It belongs to the protein kinase superfamily, CMGC ser/Thr protein kinase family and MNB/DYRK subfamilly.
||See product label
||Partial recombinant protein of human protein kinase minibrain homolog (aa 674 to 763) with a GST tag.
||Dual specificity tyrosine-phosphorylation-regulated kinase 1A; MNBH; HP86; Dual specificity YAK1-related kinase; hMNB; DYRK1A
||Protein G purified immunoglobulin
||Direct and sandwich ELISA and WB are recommended for this antibody. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Specificity has been confirmed by WB and direct ELISA against the antigen.
||This antibody cross reacts with mouse and rat protein kinase minibrain homolog proteins.
||To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it.
||Lyophilised from PBS pH 7.2
||Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
||After reconstitution keep aliquots at -20°C for higher stability or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
||12 months when stored at -20°C