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Rabbit antibody to recombinant human p75NTR: whole serum

$297.00USD


Catalogue No. R-089-100
Description FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.
Batch No. See product label
Unit size 100 uL
Antigen Extra cellular domain of human p75NTR
Other Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271 antigen
Accession TNR16_HUMAN
Produced in Rabbit
Purity Whole serum
Applications IHC, immunofluorescence. Recommended to be used at a dilution of 1:500 to 1:2000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity IHC shows specific staining for p75NTR.
Cross-reactivity This antibody is known to react to rat p75NTR.
Form Lyophilised
Reconstitution Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
Images (click to zoom)
Rabbit antibody to recombinant human p75NTR: whole serum IHC on rat spinal cord (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.
Rabbit antibody to recombinant human p75NTR: whole serum IHC on rat trigeminal nerve (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.
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MSDS

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