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Rabbit antibody to pan synuclein: whole serum

$297.00USD


Catalogue No. R-060-100
Batch No. See product label
Unit size 100 µl
Antigen A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.
Accession SYUA_HUMAN
SYUB_HUMAN
SYUG_HUMAN
Produced in Rabbit
Purity Whole serum
Applications IHC, WB and immunoblot. A dilution of 1:1000 is recommended for these applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins
Cross-reactivity This antiserum recognises human and rat alpha-, beta- and gamma synucleins.
Blast it If you would like to use this product in another species other than those specified here, or to see the shared identity between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form Lyophilised
Reconstitution Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
Specific References 1. Ulusoy A. et al (2010) Eur J Neurosci. 2010 Aug;32(3):409-22
2. Näsström T. et al (2010) The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med. 2010 Dec 1.
3. Eslamboli A. et al (2007) Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain. 2007 Mar;130(Pt 3):799-815.
4. Mukaetova-Ladinska E.B. et al (2008) Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dement Geriatr Cogn Disord. 2008;26(1):32-42.
References 1. Opazo F. et al J Neurochem. 2008 Jul;106(2):529-40
2. Lundvig, et al Brain Res Mol Brain Res 134, 3-17 (Mar 24, 2005).
3. Bennett, Pharmacol Ther 105, 311-31 (Mar, 2005).
4. Vekrellis, et al., Mol Neurobiol 30, 1-21 (Aug, 2004).
5. Martin, et al., Protein Pept Lett 11, 229-37 (Jun, 2004).
6. Doherty, et al., Acta Neuropathol (Berl) 107, 169-75 (Feb, 2004).
7. Goedert, Curr Opin Genet Dev 11, 343-51 (Jun, 2001).
8. Saito, et al., J Neurol Sci 177, 48-59 (Aug 1, 2000).
9. Lucking et al. Cell Mol Life Sci. 2000 Dec;57(13-14):1894-908.
10. Kahle, et al., Ann N Y Acad Sci 920, 33-41 (2000).
11. Clayton, et al., Trends Neurosci 21, 249-54 (Jun, 1998).
Images (click to zoom)
Rabbit antibody to pan synuclein: whole serum Immunohistochemical staining of pan synuclein in rat cochlear nucleus using rabbit polyclonal antibody to human pan synuclein, catalogue number R-060-100.

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MSDS

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