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Rabbit polyclonal antibody to human Mitofusin 2 (601-757): Affinity purified


Catalogue No. R-1793-100
Description Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). Reference:
Batch No. See product label
Unit size 100 ug
Antigen E.coli-derived recombinant protein corresponding to C-terminal region (601-757aa) from human Mitofusin-2.
Antibody Type Polyclonal
Other Names Transmembrane GTPase MFN2
Accession O95140 MFN2_HUMAN
Produced in Rabbit
Molecular Weight Human Mitofusin 2 (isoform 1) has a predicted length of 757 amino acids and MW of 86 kDa.
Purity Immunogen affinity purified
Applications Western Blotting (WB). A concentration of 0.1-0.5 ug/mL is recommended for WB. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity The specificity of this antibody has been confirmed by WB.
Species Against Human
Cross-reactivity Rat and mouse
Form Lyophilised with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3
Reconstitution Reconstitute in 100 uL sterile ultrapure water. Centrifuge to remove any insoluble material.
Storage Store lyophilized antibody at 2-8C. After reconstitution, aliquot and store at -20C for a higher stability. Avoid freeze-thaw cycles.
Expiry Date 12 months after purchase
Images (click to zoom)
Rabbit polyclonal antibody to human Mitofusin 2 (601-757): Affinity purified Detection of Mitofusin-2 protein by Western Blotting. A specific Mitofusin-2 band at 86 kDa is observed in HELA cell lysate (A), A549 cell lysate (B), rat brain (C), rat heart (D), rat kidney (E), mouse brain (F), mouse heart (G), mouse kidney (H), mouse small intestine (I) and mouse NIH3T3 cell lysate (J). Samples were loaded at 50 µg total protein per lane. SDS-PAGE: denatured and reduced; Transfer Membrane: nitrocellulose; Blocking: 5% skim milk in TBS, 1.5 hours at RT; Primary antibody: overnight at 4°C (0.5 µg/mL); Secondary antibody: anti-rabbit-HRP (1/10,000) 1.5 hours at RT; Detection: Chemiluminiscence.

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