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Saporin

$117.00USD


Catalogue No. PE-001-100
Description Saporin is a ribosome-inactivating protein (RIP) of type I. This monomeric RNA N-glycosidase purified from seeds of the plant Saponaria officinalis also known as Soapwort, is capable of specific depurination of eukaryotic ribosomes thus arresting protein synthesis. No ligand has been identified in saporin hence its inability to transverse the cell membrane. Due to its toxicity and stability of the structure, saporin has proven extremely useful for construction of immunotoxins.
Batch No. See product label
Unit size 100 ug. Bulk amounts available upon request, enquire at sales@biosensis.com
Other Names Saponaria officinalis; Common soapwort; ribosome inactivating protein saporin-6; SAP-6; SO-6; rRNA N-glycosidase
Accession RIP6_SAPOF
Produced in Purified from seeds of the plant Saponaria officinalis.
Molecular Weight 29.5 kDa
Handling Only qualified personnel should handle this product. Extreme precaution must be employed when handling the toxin. Wear lab coat, gloves and safety glasses. The toxin must not come into contact with open wounds. Practice good laboratory technique to avoid auto-exposure/auto-injection! Wash thoroughly any part of the body exposed to the toxin. Contaminated materials should be exposed to 300 mM NaOH or autoclaved.
Purity > 95% by SDS-PAGE
Biol. activity Upon introduction into the cells, saporin will arrest the protein synthesis by damaging the ribosmes.
Form Lyophilised
Reconstitution Saporin may be reconstituted in the buffer of choice for example PBS.
Storage Keep lyophilized protein at 2-8C. Aliquot and keep at -20C for long-term storage. For short term keep aliquots at 2-8C. Avoid repetitive freeze/thaw cycles.
General References Stirpe, F. et al (1983) Biochem J 216, 617-625
Images (click to zoom)
Saporin Analysis of saporin, purified from Saponaria Officinalis seeds (10 ug protein per lane), by denaturing SDS-PAGE.

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MSDS

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