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Sheep antibody to rh GDNF: affinity purified

$297.00USD


Catalogue No. S-021-50
Description GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
Batch No. See product label
Unit size 50 ug
Antigen Recombinant human GDNF
Other Names Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; hGDNF; GDNF
Accession GDNF_HUMAN
Produced in Sheep
Purity Affinity purified
Applications IHC, WB. A dilution of 1 ug/mL is recommended for both applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity No cross reactivity with NTN has been observed in western blot analysis.
Cross-reactivity This antibody is known to react with human, mouse and rat GDNF.
Blast it If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it.
Form Lyophilised
Reconstitution Reconstitute in 50 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
References Lin et al (1993) Science. 260(5111):1130-2
Images (click to zoom)
Sheep antibody to rh GDNF: affinity purified
Sheep antibody to rh GDNF: affinity purified Immunohistochemical staining of Glial Derived Neurotrophic Factor (GDNF) in rat dorsal root ganglia using sheep polyclonal antibody to recombinant human GDNF, catalogue number S-021-50.
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MSDS

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