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Sheep antibody to NT3: IgG

$297.00USD


Catalogue No. S-054-500
Description NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.
Batch No. See product label
Unit size 500 ug
Antigen A synthetic peptide (YAEHKSHRGEY) as part of human, mouse and rat NT3 protein conjugated to BSA
Other Names Neurotrophin-3; Neurotrophic factor; HDNF; Nerve growth factor 2; NGF-2; Ntf3; Ntf-3
Accession NT3_HUMAN
NT3_MOUSE
NT3_RAT
Produced in Sheep
Purity Protein G purified IgG
Applications IHC, ELISA, WB, inhibition of biological activity. A concentration of 1-10 ug/mL is recommended for IHC, ELISA, WB and inhibition of biological activity in vitro; 2-10 ug/mL (ED50) for in vivo use. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity A cross reactivity of less than 0.1% to mouse NGF, recombinant human BDNF and NT4/5 has been shown by dot blot.
Cross-reactivity This antiserum is known to react with rat, chicken and human NT3.
Blast it If you would like to use this product in another species other than those specified here, or to see the shared ID between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form Lyophilised
Reconstitution Reconstitute in 500 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months after purchase
References 1. Zouh et al. (1996) Mol. Neurobio. 13(3): 185-97
2. Rush et al. (1997) Clin. Exp. Pharmacol. 24: 549-55
3. Tafreshi et al. (1998) Neurosci. 83(2): 373-80
PDF Data Sheet

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MSDS

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