Rabbit antibody to GABARAP: whole serum

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Home » Catalog » Antibodies » Autophagy » R-143-100

Rabbit antibody to GABARAP: whole serum

$267.00USD

Catalogue No.:	R-143-100
Batch No.:	See product label
Unit size:	100 µl
Antigen:	A synthetic peptide (FEKRRSEGEKIC) corresponding to the N-terminal of human GABARAP protein has been used as the immunogen. The sequence is homologous with mouse and rat form of GABARAP.
Other Names:	Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein, MM46, GENE NAME: GABARAP, FLC3B
Accession:	GBRAP_HUMAN GBRAP_MOUSE GBRAP_RAT
Description:	GABARAP is highly positively charged in its N-terminus and shares sequence homology with MAP1LC3 1A and 1B. This protein clusters neurotransmitter receptors (GABA(A) receptors) by mediating interaction with the cytoskeleton. SUBUNIT: Interacts with GABRG2, TUBA1, ULK1 and NSF. Interacts with beta-tubulin and GPHN. SUBCELLULAR LOCATION: Intracytoplasmic membrane. Cytoskeleton. Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules. TISSUE SPECIFICITY: Heart, brain, placenta, skeletal muscle, kidney and pancreas.
Produced in:	NZ white rabbit
Purity:	Whole serum
Applications:	IHC, immunofluorescence, WB. A dilution of 1:200 to 1:1000 dilution is recommended for these applications. The optimal dilution should be determined by the end user.
Specificity:	IHC, WB and ELISA confirmed the specificity for GABARAP.
Cross-reactivity:	Human, rat. Other species not yet tested.
Form:	Lyophilised
Reconstitution:	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage:	After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date:	12 months after purchase
References:	1. Wang H. et al. Nature. 397: 69-72 (1999) 2. Okazaki N. et al. Brain Res. Mol. Brain Res. 85:1-12(2000) 3. Hu R.-M. et al. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) 4. Knight D. et al. Biol. Chem. 277:5556-5561(2002)

Images (click to zoom)

Rabbit antibody to GABARAP: whole serum

Western blot under reducing conditions on 293 cell lysate using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1:100.

	A. Confocal microscopy on immunofluorescently detected GABARAP (in red) in cytospin-isolated human white blood cells using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1: 200, incubated for 1 h at room temperature, counter-stained with Hoechst Dye. Here, the merged picture is presented.
	B. Confocal microscopy on immunofluorescently detected MHC class II (in green) in cytospin-isolated human white blood cells. The cells were counter-stained with Hoechst Dye. The merged picture is presented.
	C is the merged picture of Figures A & B. Confocal microscopy on immunofluorescently detected GABARAP in cytospin-isolated human white blood cells using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The cells were double-stained for GABARAP appearing in red and MHC class II appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented.
	Confocal microscopy on immunofluorescently detected GABARAP (in red) in cytospin-isolated human white blood cells using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1: 200, incubated for 1 h at room temperature.
	Confocal microscopy on immunofluorescently detected GABARAP in cytospin-isolated human white blood cells using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The cells were double-stained for GABARAP appearing in red and MHC class II appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented.
	Confocal microscopy on immunofluorescently detected GABARAP in cytospin-isolated human white blood cells using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1: 200, incubated for 1 h at room temperature. The cells were double-stained for GABARAP appearing in red and MHC class II appearing in green. The cells were counter stained with Hoechst Dye (blue colour). Here, the merged picture is presented.
	Western blot under reducing conditions on Odora (an Olfactory cell line) cell lysate using Rabbit antibody to GABARAP: whole serum (R-143-100) at a dilution of 1:100.

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