||Synapsin is a neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is thought to function in the regulation of neurotransmitter release. Synapsin exists as a homodimer and at the subcellular level is located at the cell junction and synapse. It interacts with CAPON and forms a ternary complex with NOS1. Synapsin is a substrate of at least four different protein kinases and it is likely that phosphorylation plays a role in its regulation in the nerve terminal. Defects in SYN1 cause X-linked recessive epilepsy associated with variable learning disabilities and behaviour disorders.
||See product label
||A synthetic phosphopeptide from the N-terminus of human synapsin
||Synapsin-1; Synapsin I; Brain protein 4.1
||WB. A dilution of 1:500- 1:1000 is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Synapsin (phospho-Ser9) antibody detects endogenous levels of synapsin only when phosphorylated at serine 9.
||This antibody is known to cross-react with mouse and rat synapsin. Other species have not yet been tested.
||If you would like to see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it.
||Reconstitute with addition of 100µl of sterile water.
||It is recommended that a thawed sample is stored at 4C for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20C or lower.
||12 months upon reconstitution
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2.Onofri, F., et,al. (2000) J. Biol. Chem ; 275: 29857.
3.Bonanomi, D., et,al. (2005) J. Neurosci; 25: 7299 - 7308.
4.Tokumitsu, H., et,al. (2005) J. Biol. Chem ; 280: 35108 - 35118.