| Catalogue No.: |
R-103-100 |
| Batch No.: |
See product label |
| Unit size: |
100 µl |
| Antigen: |
A synthetic peptide (ASTTSSF ISSPYTSVDE YS) corresponding to the absolute C-terminal of rat NK-3 receptor protein (aa: 434-452) conjugated to KLH |
| Other Names: |
Neuromedin K receptor, NKR, Neurokinin B receptor, NK-3 receptor, NK-3R, Tachykinin receptor 3. GENE NAME: Tacr3; Tac3r |
| Accession: |
NK3R_RAT |
| Description: |
FUNCTION: This is a receptor for the tachykinin neuropeptide neuromedin K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. PTM: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. MISCELLANEOUS: The rank order of affinity of this receptor to tachykinins is: neuromedin K > substance K > substance P. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. |
| Produced in: |
NZ white rabbit |
| Purity: |
Whole serum |
| Applications: |
WB. A dilution of 1:500 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Specificity: |
Specificity has been shown by western blot using rat brain homogenate. A band of 66 kDa, the theoretical MW of NK-3R, could be easily detected. |
| Cross-react: |
This antiserum is know to cross react with rat NK-3 R. |
| Blast it: |
If you would like to use this product in another species other than those specified here, or to see the shared ID between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this. |
| Form: |
Lyophilised |
| Reconstitution: |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage: |
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. |
| References: |
Mileusnic, D. et al. (1999). Neuroscience. 89(4): 1269. |
| Related items: |
R-105-100, S-031-100, S-032-100, R-104-100 |
