Rabbit antibody to Peroxiredoxin-6 (NSGPx): whole serum

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Home » Catalog » Antibodies » Antioxidant Enzymes » R-169-100

Rabbit antibody to Peroxiredoxin-6 (NSGPx): whole serum

$190.00USD

Catalogue No.:	R-169-100
Batch No.:	See product label
Unit size:	100 µl
Antigen:	Rat recombinant Peroxiredoxin-6. The sequence is homologous in human and mouse peroxiredoxin-6.
Other Names:	Non-selenium glutathione peroxidase, antioxidant protein 2, 1-Cys peroxiredoxin, 1-Cys PRX, Acidic calcium-independent phospholipase A2, NSGPx, Thiol-specific antioxidant protein. GENE NAME: Prdx6; Aipla2; Aop2; Tsa
Accession:	PRDX6_RAT PRDX6_HUMAN PRDX6_MOUSE
Description:	FUNCTION: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Also found in lung secretory organelles. MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin . MISCELLANEOUS: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.
Produced in:	NZ white rabbit
Purity:	Whole serum
Applications:	IHC, WB, ELISA. This antibody works superbly in Immunohistochemistry on frozen or paraffin embedded tissues. Antigen retrieval has been used in testing but may not be necessary. Typical working dilutions for routine immunohistochemistry are 1: 100 to 1: 1000 depending on tissue and detection method. For western blotting a dilution range of 1: 1000 to 1: 4000 is recommended. A dilution of 1: 1000 to 1: 4000 is recommended for ELISA. The optimal dilution should be determined by the end user. This antiserum stains the cytoplasm of epithelial cells in the rat and mouse lung and rat and human brain astrocytes. It stains human brain astrocytes in Parkinson's and Alzheimer's disease and the central core of some Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Other tissues have not yet been tested.
Specificity:	This antibody has been shown to be specific for Peroxiredoxin-6 protein.
Cross-react:	Rat, human and mouse, other species have not yet been tested.
Blast it:	If you would like to use this product in another speices other than those specified here, or to see the shared identity between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form:	Lyophilised
Reconstitution:	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage:	After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.
Expiry Date:	12 months after purchase
References:	1. Kim T.-S, et al. J. Biol. Chem. 272:2542-2550(1997). 2. Choi H.-J, et al. Nat. Struct. Biol. 5:400-406(1998). 3. Rush J, et al. Nat. Biotechnol. 23:94-101(2005). 4. Wagner E, et al. Biochem. J. 366:777-785(2002). 5. Chen J.-W, et al. J. Biol. Chem. 275:28421-28427(2000). 6. Kang S.W, et al. J. Biol. Chem. 273:6303-6311(1998). 7. Gevaert K, et al. Nat. Biotechnol. 21:566-569(2003). 8. Gregory S.G, et al. ature 441:315-321(2006). 9. Nagase T, et al. DNA Res. 2:37-43(1995). 10. Frank S, et al. Oncogene 14:915-921(1997). 11. Power J, et al. Am J. Path. 161: 885-894 (2202). 12. Power J, et al. Experimental Lung Res. 25: 379-391(1999).
Related items:	S-073-100, R-168-100, R-171-100, R-125-100, R-126-100, R-170-100, S-072-100

PDF Data Sheet	- Click to download the Data Sheet
MSDS	- Click to download the Material Safety Data Sheet

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