Rabbit antibody to Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum

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Home » Catalog » Antibodies » Neurotrophic Receptors » R-121-100

Rabbit antibody to Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum

$190.00USD

Catalogue No.:	R-121-100
Batch No.:	See product label
Unit size:	100 µl
Antigen:	A synthetic peptide (AFPRLEPNSIDPENC) as part of rat TrkB (aa: 23-36) conjugated to KLH
Other Names:	BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B. GENE NAME: Ntrk2; Trkb
Accession:	NTRK2_RAT
Description:	FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain.
Produced in:	NZ white rabbit
Purity:	Whole serum
Applications:	IHC. A dilution of 1:1000 to 1:3000 is recommended for this application. The optimal working dilution should be determined by the end user. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics.
Specificity:	Sequence was chosen to avoid cross reactivity with TrkA and TrkC.
Cross-react:	This antiserum recognises human and rat TrkB. Cross reactivity with other species has not yet been tested.
Blast it:	If you would like to use this product in another species other than those specified here, or to see the shared identity between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form:	Lyophilised
Reconstitution:	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage:	After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date:	12 months after purchase
References:	1. Yan Q et al. J Comp Neurol 378:135-57 (1997). 2. Stoilov, P., et al., Biochem. Biophys. Res. Commun. 290(3):1054-1065 (2002). 3. Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). 4. Nakagawara, A., et al., Genomics 25(2):538-546 (1995). 5. Haniu, M., et al., Arch. Biochem. Biophys. 322(1):256-264 (1995). 6. Allen, S.J., et al., Neuroscience 60(3):825-834 (1994).
Related items:	T-001-100, M-009-100, M-006-50, R-067-100, R-068-100, R-089-100, R-152-100, R-151-100, R-149-100, S-010-100

Images

Rabbit antibody to Tyrosine Kinase Receptor B (TrkB; 23-36): whole serum

Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat spinal cord using rabbit polyclonal antibody to rat TrkB, catalogue number R-121-100.

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