| Catalogue No.: |
R-151-100 |
| Batch No.: |
See product label |
| Unit size: |
100 µl |
| Antigen: |
Extracellular domain of glycosylated human TrkC protein produced in CHO cells was used as the immunogen. |
| Other Names: |
Tropomyosin-related kinase receptor, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C. GENE NAME: NTRK3, TRKC |
| Accession: |
NTRK3_HUMAN |
| Description: |
TrkC is a member of the neurotrophic tyrosine receptor kinase family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3). Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Mutations in TrkC have been associated with medulloblastomas, secretory breast carcinomas and other cancers. |
| Produced in: |
NZ white rabbit |
| Purity: |
Whole serum |
| Applications: |
IHC. A dilution of 1:1000 to 1:3000 is recommended for this application. The optimal working dilution should be determined by the end user. |
| Specificity: |
Specificity was demonstrated by immunohistochemistry. This antibody was used to stain cryostat sections of the rat peripheral sensory ganglia. |
| Cross-reactivity: |
Reacts with human, rat and mouse TrkC. Other species have not yet been tested. |
| Form: |
Lyophilised |
| Reconstitution: |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage: |
After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. |
| References: |
Zhang FX, et al. (2005) Brain Res. 1062 (1-2) pp. 92-100. |
