Sheep antibody to rh BDNF: Whole serum

Products

Alzheimer's / Parkinson's

Antioxidant Enzymes

Cell Cycle Regulators

Diabetes & Obesity

DNA Damage & Repair

G-Protein Coupled Receptors

Intracellular Trafficking

Junction Proteins

Matrix & Adhesion Molecules

Neuronal Markers

Neuropeptides & Receptors

Neurotransmitters & Enzymes

Neurotrophic Factor Receptors

Neurotrophic Factors

Receptors & Channel Molecules

Sensory Nervous System

Signaling Molecules & TF

Synaptic Function

Tracing Reagents

Control Peptides and Antibodies

FOLLOW US...

Sign up for biosensis Product Features

Visit our newsletter archive

Antibodies » Neurotrophic Factors » S-016-100

Sheep antibody to rh BDNF: Whole serum

$287.00USD

Catalogue No.	S-016-100
Description	BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
Batch No.	See product label
Unit size	100 µl
Antigen	Recombinant human BDNF
Other Names	Brain-derived neurotrophic factor; Abrineurin; proBDNF;
Accession	BDNF_HUMAN
Produced in	Sheep
Purity	Whole serum
Applications	IHC, ELISA, Western Blot, inhibition of biological activity in vitro/in vivo. Recommended to be used at a dilution of 1:200-2000 for immunohistochemistry, ELISA and Western blot. 1:10 to 1:50 for inhibition of biological activity in vitro. Use neat for in vivo studies at 5-10 µl/g body weight. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity	A cross reactivity of less than 1% against mouse NGF, recombinant human NT3 or NT4/5 has been shown by one site ELISA.
Cross-reactivity	This antiserum recognises BDNF from rat, mouse and human.
Blast it	If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it.
Form	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date	12 months after purchase
References	1. A Acheson et al (1995) Nat. 74: 450-3 2. Q Yan et al (1994) J. Neurosci. 14(9): 5281-91 3. XF Zhou et al (1996) Neurosci. 74: 945-53 4. XF Zhou, et al (1998) Exp. Neurol. 149: 237-42 5. B Mellstrom et al (2004) Crit Rev Neurobiol 16, 43-9 6. I Tapia-Arancibia et al (2004) Front Neuroendocrinol 25, 77-107 7. S Pezet, et al (2002) Brain Res Brain Res Rev 40, 240-9

PDF Data Sheet	- Click to download the Data Sheet
MSDS	- Click to download the MSDS

Customers who bought this product also purchased

Sheep antibody to rh Basic FGF: whole serum

My Ice Bucket

0 items

Currencies

Email This Page

We Accept PayPal

Click to make a payment