| Catalogue No. |
S-079-100 |
| Description |
Brain derived neurotrophic factor (BDNF) is synthesized as a precursor (proBDNF) which may be released and have physiological functions to cause cell death. It binds neurotrophin receptor p75 and sortilin and may also be important for the development of nervous system. proBDNF is synthesized in neurons and glia, transported anterogradely and retrogradely and may be released in an activity dependent manner. This antibody is raised in sheep to detect the prodomain of BDNF not the mature peptide. |
| Batch No. |
See product label |
| Unit size |
100 µl |
| Antigen |
The recombinant prodomain fragment of human brain-derived neurotrophic factor |
| Other Names |
Proform brain derived neurotrophic factor |
| Accession |
ProBDNF_HUMAN |
| Produced in |
Sheep |
| Purity |
Whole Serum |
| Applications |
ELISA, Western Blot, biological neutralization of proBDNF. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. |
| Specificity |
Confirmed to react with purified human proBDNF, crossreact with mouse and rat proBDNF |
| Cross-reactivity |
Cross reactivity with other species than human have not yet been tested |
| Blast it |
If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it. |
| Form |
Lyophilised |
| Reconstitution |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
After reconstitution keep aliquots at –20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. |
| Expiry Date |
12 months after purchase |
| References |
1. Fan, YJ. et al (2008) Eur J Neurosci 27(9):2380-90. |
