Beta-Synuclein, Rabbit Polyclonal Antibody

As low as US$317.00
Only %1 left
Catalog Number
R-2105

    Product Info

  • Product Name Beta-Synuclein, Rabbit Polyclonal Antibody
  • Product Description google Rabbit anti-Beta-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
  • Alternative Names Beta-synuclein, β-synuclein
  • Application(s) IHC-Frozen, WB
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Specificity Specific for β-synuclein, does not cross-react with α- or γ-synuclein.
  • Species Reactivity Human, Mouse, Rat
  • Immunogen Description Full-length human recombinant β-synuclein protein expressed in and purified from E. Coli.
  • Conjugate Unconjugated
  • Purity Description Affinity Purified
  • Regulatory Status For research use only.

    Specifications

  • Product Description Rabbit anti-Beta-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
  • Related Products Beta-Synuclein, Mouse Monoclonal Antibody
    Beta-synuclein, Rabbit Polyclonal Antibody
    Synuclein, pan, Rabbit Polyclonal Antibody
    Beta-synuclein, Rabbit Polyclonal Antibody
    Synuclein, pan, Rabbit Polyclonal Antibody
    Beta-synuclein, Sheep Polyclonal Antibody
    Pan-synuclein, Sheep Polyclonal Antibody
    Beta-synuclein, Sheep Polyclonal Antibody
  • Application(s) IHC-Frozen, WB
  • Application Details Western blotting (1:1,000-1:2,000) and Immunohistochemistry (frozen sections, 1:1,000-1:2,000). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Product Validation Validated by western blotting and immunohistochemical procedures.
  • Target Beta-synuclein (β-synuclein, SNCB)
  • Specificity Specific for β-synuclein, does not cross-react with α- or γ-synuclein.
  • Target Host Species Human
  • Species Reactivity Human, Mouse, Rat
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Antibody Isotype IgG
  • Conjugate Unconjugated
  • Immunogen Description Full-length human recombinant β-synuclein protein expressed in and purified from E. Coli.
  • Immunogen Length Full-length recombinant protein.
  • Purity Description Affinity Purified
  • Physical State Solid.
  • Format Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at -20°C for long-term storage. Store at 2-8°C short-term (up to 4 weeks). Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Beta-synuclein, β-synuclein
  • Uniprot Number Q16143
  • Uniprot Number/Name Q16143 (SYUB_HUMAN)
  • Cellular Localization Intracellular, cytosolic.
  • Scientific Background Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease (Ref: uniprot.org).
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Left: Analysis of beta-synuclein expression in rat cerebellum section by Immunohistochemistry. Beta-synuclein (red) was detected with rabbit antibody to beta-synuclein (1:1,000), and sections co-stained with chicken antibody to parvalbumin (C-1814-50, green, 1:5,000). Blue: Hoechst nuclear stain. IHC Method: Following transcardial perfusion of mouse with 4% paraformaldehyde, brain was post-fixed for 24 hours, cut to 45 μm, and free-floating sections were stained with above antibodies. The beta-synuclein antibody detects protein concentrated in synaptic regions, while the parvalbumin antibody labels the perikarya and dendrites of Purkinje cells and interneurons in the molecular layer of the cerebellum. Right: Western blot analysis of tissue homogenates using rabbit antibody to beta-synuclein (green, 1:1,000). Lane 1: molecular weight marker; Lane 2: mouse cerebellum; Lane 3: mouse hippocampus; Lane 4: rat cerebellum; Lane 5: rat hippocampus; Lane 6: cow cerebellum. A strong band at about 17 kDa corresponds to beta-synuclein protein.

    Citations & References