Application DetailsEnzyme-Linked Immunosorbent Assay (ELISA), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC). A dilution of 1:500 - 1:2,000 is recommended for WB. A dilution of 1:200 – 1:1,000 is recommended for IF and 1:100 – 1:300 for IHC. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
SpecificityHuman, mouse, and rat. No cross reactivity with other proteins.
Target Host SpeciesHuman
Species ReactivityHuman, Mouse, Rat
Immunogen DescriptionThe antibody has been made against a synthetic peptide derived from human beta-synuclein.
Purity DescriptionAffinity purified from rabbit antiserum using the immunogen.
FormatLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Refer to the product label for antibody concentration.
Storage InstructionsAliquot and store at -20°C for a higher stability; Store at 4°C for up to one month for short term storage and frequent use. Avoid freeze-thaw cycles.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Scientific BackgroundBeta-Syncuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine stimulated capsase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This is also associated with the disease Brain iron accumulation type 1 (NBIA1). (Ref: uniprot.org)