Neurons and glia communicate to each other via a specialized cellular junction called the synapse. The synapse allows one neuron to pass an electrical or chemical signal to another cell. At a synapse, the cell membrane of the signal-passing neuron (the presynaptic neuron) comes into close apposition with the membrane of the target (postsynaptic) cell. Both the presynaptic and postsynaptic sites contain multiple protein complexes that functionally link the two membranes together and carry out the signaling process. There are both chemical synapses where electrical the activity of the presynaptic cell is converted in a chemical signal via the release of neurotransmitters that bind specific receptor proteins, often called G-protein coupled receptors that are embedded in the postsynaptic cell and allow the chemical signal to be convert into intracellular signaling events, and electrical synapses where the presynaptic and postsynaptic cells are physically connected via gap junctions and electrical current is transferred directly back and forth between cells ultimately governing the cell polarization state.
Biosensis is proud to offer an extensive antibody range targeting many important proteins involved in the maintenance function and recycling of synapses. We also offer numerous antibodies targeted to the various receptors including the neurokinin-3 receptor, PTH2 receptor, Endothelin B receptor, Chemokine receptors, dopamine receptor, Orexin receptor and histamine receptor as well as multiple antibodies targeting neurotransmitters and the enzymes necessary for the production, transport or release.