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Integrin beta-7, Rabbit Recombinant Antibody
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Catalog Number
R-2044
- Product Name Integrin beta-7, Rabbit Recombinant Antibody
- Product Description Rabbit anti-Integrin beta-7 Recombinant Antibody (Unconjugated), suitable for ICC, FC, Block.
- Alternative Names FIB-27; FIB 27; Fib-27; Fib27; Fib 27; fib27; fib-27; fib 27; Integrin b7; integrin b-7; ITGB7; Gut homing receptor beta subunit
- Application(s) Block, FC, ICC
- Antibody Host Rabbit
- Antibody Type Recombinant
- Specificity FIB504 recognizes an epitope on intergin beta-7 subunit that overlaps completely with the epitope defined by Fib27 and Fib30, and also partially with the epitope defined by FIB21 and FIB22. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
- Species Reactivity Human, Mouse
- Immunogen Description FIB504 was prepared by immunizing rats with TK1 cells.
- Conjugate Unconjugated
- Concentration 1 mg/mL
- Purity Description Purified antibody, via affinity chromatography
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Integrin beta-7 Recombinant Antibody (Unconjugated), suitable for ICC, FC, Block.
- Application(s) Block, FC, ICC
- Application Details FIB504 can be used for IF, FC and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion.
- Target Integrin beta-7
- Specificity FIB504 recognizes an epitope on intergin beta-7 subunit that overlaps completely with the epitope defined by Fib27 and Fib30, and also partially with the epitope defined by FIB21 and FIB22. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
- Target Host Species Human
- Species Reactivity Human, Mouse
- Antibody Host Rabbit
- Antibody Type Recombinant
- Antibody Isotype IgG, kappa
- Clone Name FIB504
- Conjugate Unconjugated
- Immunogen Description FIB504 was prepared by immunizing rats with TK1 cells.
- Purity Description Purified antibody, via affinity chromatography
- Format Liquid. PBS with 0.02% Proclin 300.
- Concentration 1 mg/mL
- Storage Instructions Store at 2-8°C for up to 1 month. For longer storage, aliquot and store at -20_C. Avoid mulitiple freeze thaw cycles.
- Batch Number Please see item label.
- Expiration Date Store at 2-8⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C for up to 12 months.
- Alternative Names FIB-27; FIB 27; Fib-27; Fib27; Fib 27; fib27; fib-27; fib 27; Integrin b7; integrin b-7; ITGB7; Gut homing receptor beta subunit
- Uniprot Number P26010
- Uniprot Number/Name P26010 (ITB7_HUMAN)
- Scientific Background This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. FIB504 can be used for IF, FC and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
