Product DescriptionIvermectin, Purified Small Molecule, suitable to Neutralize.
Application DetailsPositive allosteric modulator of the alpha-7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
Target Host SpeciesSpecies Independent
Purity Description>98% (TLC); NMR (Conforms) Contains up to 10% B1b form.
Purity %> 98%
FormatDry, white powder.
Reconstitution InstructionsSoluble in DMSO. May be dissolved in DMSO up to 40 mg/mL.
Storage InstructionsStore desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
Batch NumberPlease see item label.
Expiration DateStore desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
Alternative NamesIvermectin B1a; Dihydroavermectin B1a; CAS 70288-86-7
Scientific BackgroundPharmacology: A specific inhibitor of importin alpha/beta-mediated nuclear import with no effect on a range of other nuclear import pathways (1). Displays potent antiviral activity against HIV-1, dengue (1), corona (2) and other viruses. Clinically useful broad-spectrum antiparasitic agent (3). PubChem CID: 6321424.
Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.