Ivermectin, Purified Small Molecule

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Catalog Number
PE-1843

    Product Info

  • Product Name Ivermectin, Purified Small Molecule
  • Product Description google Ivermectin, Purified Small Molecule, suitable to Neutralize.
  • Alternative Names Ivermectin B1a; Dihydroavermectin B1a; CAS 70288-86-7
  • Application(s) Neutralize
  • Purity Description >98% (TLC); NMR (Conforms) Contains up to 10% B1b form.
  • Purity % > 98%
  • Regulatory Status For research use only.

    Specifications

  • Product Description Ivermectin, Purified Small Molecule, suitable to Neutralize.
  • Application(s) Neutralize
  • Application Details Positive allosteric modulator of the alpha-7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
  • Target Ivermectin
  • Target Host Species Species Independent
  • Purity Description >98% (TLC); NMR (Conforms) Contains up to 10% B1b form.
  • Purity % > 98%
  • Format Dry, white powder.
  • Reconstitution Instructions Soluble in DMSO. May be dissolved in DMSO up to 40 mg/mL.
  • Storage Instructions Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Alternative Names Ivermectin B1a; Dihydroavermectin B1a; CAS 70288-86-7
  • Scientific Background Pharmacology: A specific inhibitor of importin alpha/beta-mediated nuclear import with no effect on a range of other nuclear import pathways (1). Displays potent antiviral activity against HIV-1, dengue (1), corona (2) and other viruses. Clinically useful broad-spectrum antiparasitic agent (3). PubChem CID: 6321424.

    Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 12352401
  • Regulatory Status For research use only.

    Citations & References

  • General References KM Wagstaff et al. Biochem. J. 2012 443:851
    L Caly et al. Antiviral Res. 2020 104787
    EA Ottesen and WC Campbell J. Antimicrob. Chemother. 1994 34:195