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Alpha-synuclein, Mouse Monoclonal Antibody
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Catalog Number
M-1402
- Product Name Alpha-synuclein, Mouse Monoclonal Antibody
- Product Description Mouse anti-Alpha-synuclein Monoclonal Antibody (Unconjugated), suitable for WB, ICC.
- Alternative Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
- Application(s) ICC, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity The specificity of this antibody has been confirmed by WB. This antibody detects ~14-15 kDa alpha synuclein protein. The epitope for 3H9 is in the region 61-95 which correspond to the Non-Amyloid beta Component of Alzheimer's disease amyloid (NAC) region. 3H9 will also bind human alpha-synuclein containing the A30P and A53T mutations. Human, horse, cow, pig, chicken, rat, mouse. Predicted to react with other mammalian tissue because of highly conserved nature of the protein.
- Species Reactivity Bovine, Chicken, Horse, Human, Mouse, Other Mammals (Predicted), Pig, Rat
- Immunogen Description Recombinant full length human alpha synuclein expressed and purified from E. coli
- Conjugate Unconjugated
- Purity Description Protein G purified mouse IgG
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Alpha-synuclein Monoclonal Antibody (Unconjugated), suitable for WB, ICC.
- Application(s) ICC, WB
- Application Details Western Blotting (WB) and Immunocytochemistry (IC/IF). A dilution of 1:1,000 - 1:5,000 is recommended for WB. A dilution of 1:500-3,000 is recommended for IC/IF. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Alpha-synuclein
- Specificity The specificity of this antibody has been confirmed by WB. This antibody detects ~14-15 kDa alpha synuclein protein. The epitope for 3H9 is in the region 61-95 which correspond to the Non-Amyloid beta Component of Alzheimer's disease amyloid (NAC) region. 3H9 will also bind human alpha-synuclein containing the A30P and A53T mutations. Human, horse, cow, pig, chicken, rat, mouse. Predicted to react with other mammalian tissue because of highly conserved nature of the protein.
- Target Host Species Human
- Species Reactivity Bovine, Chicken, Horse, Human, Mouse, Other Mammals (Predicted), Pig, Rat
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG1
- Clone Name 3H9
- Conjugate Unconjugated
- Immunogen Description Recombinant full length human alpha synuclein expressed and purified from E. coli
- Purity Description Protein G purified mouse IgG
- Format Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, without preservatives
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Final buffer contains 0.05% sodium azide as a preservative
- Storage Instructions After reconstitution of lyophilized antibody, divide into single use aliquots and store at -20-80°C for a higher stability. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
- Uniprot Number P37840
- Uniprot Number/Name P37840 (SYUA_HUMAN)
- Scientific Background Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. FUNCTION: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. TISSUE SPECIFICITY: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.SUBUNIT: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1. Interacts with phospholipase D and histones. SUBCELLULAR LOCATION: Cytoplasm. Membrane. Nucleus. Note=Membrane-bound in dopaminergic neurons. Also found in the nucleus. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
