Product DescriptionMouse anti-Dihydropyrimidinase-related protein 3 (DRP-3) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
Application DetailsThis antibody is recommended for WB and direct ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
TargetDihydropyrimidinase-related protein 3 (DRP-3)
SpecificityThe specificity of this antibody has been shown by WB and ELISA against the GST tagged recombinant DRP-3 protein. This antibody cross reacts with mouse and rat DRP-3 protein.
Target Host SpeciesHuman
Species ReactivityHuman, Mouse, Rat
Immunogen DescriptionPartial recombinant protein of human DRP-3 (amino acids 457 to 556) with a GST tag.
Purity DescriptionProtein G purified immunoglobulin
FormatLyophilized from PBS pH 7.2
Reconstitution InstructionsSpin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
Storage InstructionsAfter reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Alternative NamesDihydropyrimidinase-related protein 3; unc-33-like phoshoprotein; ULIP protein; collapsin response mediator protein 4; CRMP-4; DPSYL3; CRMP4; DRP3; ULIP
DRP-3 belongs to the hydantoinase/dihydropyrimidase subfamily. It is required for signalling by class 3 semaphorins and remodelling of the cytoskeleton. It also plays a role in axon guidance, neuronal growth cone collapse and cell migration. It exists as a homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. The unprocessed precursor is 570 amino acids long and has an estimated molecular weight of 61.9 kDa. It is mainly expressed in heart and skeletal muscle but is also strongly expressed in fetal brain and spinal cord. It localises to the cytoplasm and growth cone. This protein interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.