Product DescriptionMouse anti-Ectoderm-heural cortex protein 1 (ENC-1) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
Application DetailsThis antibody is recommended for WB, and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
TargetEctoderm-heural cortex protein 1 (ENC-1)
SpecificitySpecificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
Target Host SpeciesHuman
Immunogen DescriptionPartial recombinant human ENC-1 (amino acids 17-98) with a GST tag.
Purity DescriptionProtein G purified immunoglobulin
FormatLyophilized from PBS pH 7.2
Reconstitution InstructionsSpin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
Storage InstructionsAfter reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Alternative NamesEctodermal-neural cortex protein 1; p53-induced gene 10 protein; Nuclear matrix protein NRP/B; ENC1; NRPB; PIG10
ENC-1 is an actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It is a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target protein. It is detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. It is highly exprssed in adult brain, especially in the hippocampus and amygdala, and spinal cord. It is dramatically up-regulated upon neuronal differentiation.