Copine 6 belongs to the copine family and contains two C2 domains and one von Willebrand factor A domain. The unprocessed precursor has a length of 557 amino acids and a predicted molecular weight of 62 kDa. This protein exhibits calcium-dependent phospholipid binding properties and is thought to function in membrane trafficking and in synaptic plasticity.
Western blot detection of recombinant GST tagged human copine 6 using mouse monoclonal antibody to human copine 6 [6D11], catalogue number M-816-100. This antibody detects a band of 87.4 kDa. Note the GST tag has a MW of 26 kDa.