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Hairy and enhancer of split-related protein 1 (HESR-1), Mouse Monoclonal Antibody
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Catalog Number
M-893
- Product Name Hairy and enhancer of split-related protein 1 (HESR-1), Mouse Monoclonal Antibody
- Product Description Mouse anti-Hairy and enhancer of split-related protein 1 (HESR-1) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Hairy/enhancer-of-aplit related with YRPW motif protein 1; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; jHRT1; Cardiovascular helix-loop-helix factor 2; CHF-2; HES-related repressor protein 1; HEY1; CHF2; HERP2; HESR1; HRT1
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant human HESR1 (121-221) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Hairy and enhancer of split-related protein 1 (HESR-1) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Hairy and enhancer of split-related protein 1 (HESR-1)
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 1E10
- Conjugate Unconjugated
- Immunogen Description Partial recombinant human HESR1 (121-221) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS pH 7.2
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Hairy/enhancer-of-aplit related with YRPW motif protein 1; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; jHRT1; Cardiovascular helix-loop-helix factor 2; CHF-2; HES-related repressor protein 1; HEY1; CHF2; HERP2; HESR1; HRT1
- Uniprot Number Q9Y5J3
- Uniprot Number/Name Q9Y5J3 (HEY1_HUMAN)
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Scientific Background
HESR-1 belongs to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the the cardiac transcriptional activators GATA4 and GATA6. HESR1 is expressed in the somitic mesoderm, the central nervous system, the kidney, the heart, nasal epithelium, and limbs.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
