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Neurogenic locus notch homolog protein 2 (Notch 2), Mouse Polyclonal Antibody
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Catalog Number
Mo-933
- Product Name Neurogenic locus notch homolog protein 2 (Notch 2), Mouse Polyclonal Antibody
- Product Description Mouse anti-Neurogenic locus notch homolog protein 2 (Notch 2) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Neurogenic locus notch homolog protein 2; hN2; NOTCH2
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Polyclonal
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant human Notch 2 (26-136) with a GST tag.
- Conjugate Unconjugated
- Purity Description Whole serum
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Neurogenic locus notch homolog protein 2 (Notch 2) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Neurogenic locus notch homolog protein 2 (Notch 2)
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Polyclonal
- Antibody Isotype Mixed
- Conjugate Unconjugated
- Immunogen Description Partial recombinant human Notch 2 (26-136) with a GST tag.
- Purity Description Whole serum
- Format Liquid. 50% glycerol
- Storage Instructions Keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Neurogenic locus notch homolog protein 2; hN2; NOTCH2
- Uniprot Number Q04721
- Uniprot Number/Name Q04721 (NOTC2_HUMAN)
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Scientific Background
Notch 2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. It is expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Defects in Nothch 2 are the cause of Alagille syndrome type 2 which is a multisystem disorder defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal and opthalmologic manifestations.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
