Product DescriptionN4-Hydroxycytidine (HC), Purified Small Molecule, suitable to Neutralize.
Application DetailsBeta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon RNA reduction in Huh7 cells; also is a novel inhibitor of CHIKV (Chikungunya virus), inhibits venezuelan equine encephalitis virus (VEEV) with EC50 of <1 uM (8-11).
Target Host SpeciesSpecies Independent
Purity Description>98% (HPLC); NMR (Conforms)
Purity %> 98%
FormatDry, white powder.
Reconstitution InstructionsSoluble in DMSO or slightly in water. May be dissolved in DMSO up to 25 mg/mL; water (15 mg/mL).
Storage InstructionsStore desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
Batch NumberPlease see item label.
Expiration DateStore desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
Alternative Names_-D-N4-hydroxycytidine; NHC; CAS 3258-02-4
Scientific BackgroundPharmacology: N4-Hydroxycytidine was originally identified as a mutagen effecting AT to GC base-pair transitions (1). It has also been found to have antiviral properties against a broad range of viruses including hepatitis C (2), norovirus (3), Ebola virus (4), influenza and respiratory syncytial viruses (5) and coronaviruses (6). Active molecule in the antiviral pro-drug clinical candidate EIDD-28017. PubChem CID: 197020.
Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.