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Noggin, Human, Purified Recombinant Protein
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Catalog Number
PE-1245
- Product Name Noggin, Human, Purified Recombinant Protein
- Product Description Noggin, Human, Purified Recombinant Protein, suitable for Cell Culture.
- Alternative Names Nog;
- Application(s) Cell Culture
- Purity Description >95% as determined by SDS-PAGE and visualized by silver stain.
- Purity % > 95%
- Regulatory Status For research use only.
Product Info
- Product Description Noggin, Human, Purified Recombinant Protein, suitable for Cell Culture.
- Application(s) Cell Culture
- Target Noggin
- Target Host Species Human
- Antigen Produced In HEK293
- Sequence A DNA sequence encoding human Noggin protein (containing the signal peptide sequence and the mature human noggin sequence) was expressed in modified human 293 cells.
- Purity Description >95% as determined by SDS-PAGE and visualized by silver stain.
- Purity % > 95%
- Format The Noggin product consists of 5-25% carbohydrate by weight.
- Reconstitution Instructions Reconstitute with sterile-filtered phosphate-buffered saline to a concentration of 20 µg/mL.
- Storage Instructions Lyophilized products should be stored at 2-8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Nog;
- Uniprot Number Q13253
- Uniprot Number/Name Q13253 (NOGG_HUMAN)
- Scientific Background Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), of multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 12352202
- Regulatory Status For research use only.