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FTY-720 HCl (25 mg)


Catalogue No. PE-1855-25
Description Pharmacology: An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3) (1). Potently inhibits regulatory T cell proliferation in vitro and in vivo (2). Enhances microvascular remodeling via expansion of arterioles and capillary networks (3). Potent immunomodulator (4). Clinically effective agent for relapsing forms of multiple sclerosis (5). PubChem CID:107969

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Batch No. See product label.
Unit size 25 mg
Other Names Fingolimod Hydrochloride; CAS # 162359-56-0; FTY720; Fingolimod HCl; Gilenia; Gilenya; Fty 720
Molecular Weight 343.9 g/mol. Molecular Formula: C19H34ClNO2
Compound Name 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
Purity >98% (HPLC); NMR (Conforms)
Biol. activity Fingolimod hydrochloride is the hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod). It has a role as a sphingosine-1-phosphate receptor agonist, an immunosuppressive agent and a prodrug. It is a hydrochloride and an organic salt. It contains a fingolimod(1+).
Applications Biochemical inhibition.
Appearance Dry, white powder.
Reconstitution Soluble in DMSO. May be dissolved in DMSO up to 100 mg/mL, or ethanol up to 40 mg/mL
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. V Brinkmann et al. J. Biol. Chem. 2002 277:21453 2. AM Wolf et al. J. Immunol. 2009 183:3751
3. AO Awojoodu et al. Proc. Natl. Acad. Sci. USA 2013 110:13785
4. K Chiba Pharmacol. Ther. 2005 108:308
5. T Ziemssen et al. J. Neurol. 2016 263:1053
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FTY-720 HCl (25 mg)

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