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Camostat Mesylate (50 mg)


Catalogue No. PE-1842-50
Description Pharmacology: A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis (1). Reduces weight gain and improves metabolism in obese rodent models (2). In clinical use (in Japan) for pancreatitis (3). Inhibits influenza virus replication in human tracheal epithelial cells (4). Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming (5). PubChem CID: 5284360

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Batch No. See product label.
Unit size 50 mg
Other Names Camostat Methanesulfonate;Camostat (mesylate); FOY 305; FOY-305; Foipan; CAS 59721-29-8
Molecular Weight 494.5 g/mol. Molecular Formula: C21H26N4O8S
Compound Name 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesulfonic acid salt
Purity >98% by HPLC; NMR (Conforms)
Biol. activity Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.
Applications Biochemical inhibition.
Appearance Dry powder, off-white.
Reconstitution Soluble in water or DMSO. May be dissolved in DMSO up to 50 mg/mL, or water (50 mg/mL)
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. J Gibo et al. Lab. Invest. 2005 85:75
2. K Albarazanji et al. Am. J. Physiol. Gastrointest. Liver Physiol. 2019 316:G653
3. M Ueda et al. Nephron 2015 129:223
4. M Yamaya et al. Pulm. Pharmacol. Ther. 2015 33:66
MSDS Click to download the Material Safety Data SheetBiosensis SDS Camostat mesylate_4-30-2020.pdf
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Camostat Mesylate (50 mg)

PDF Data Sheet

Click to download the data sheet - Click to download the Data Sheet

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