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Favipiravir (5 mg)


Catalogue No. PE-1852-5
Description Pharmacology: Favipiravir is an inhibitor of influenza viruses A, B, and C (IC50s: A = 0.03-0.20 μg/mL H1N1; 0.01-0.30 H2N2; 0.08-0.48 H3N2; 0.14-0.15 H4N2; 0.24-1.60 H7N2;0.20-0.82 H5N1; 0.35 H1N2; B = 0.04-0.09 μg/mL; C = 0.03-0.06 μg/mL) as well as strains resistant to adamantane-type antivirals, oseltamivir, and zanamivir (1-3). It displays no cytotoxicity in a variety of cell lines. Selectively inhibits viral RNA-dependent RNA polymerase (4). Displays activity against other viruses including arena, phlebo, hanta, flavi, entero, alpla, respiratory syncytial, and noroviruses (5). In clinical trials for treatment of SARSCoV-2 (6,7). PubChem CID: 492405

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Batch No. See product label
Unit size 5 mg
Other Names 6-Fluoro-3-hydroxypyrazine-2-carboxamide; CAS 259793-96-9; T-705
Molecular Weight 157.1 g/mol Molecular Formula: C5H4FN3O2
Compound Name 6-Fluoro-3-hydroxypyrazine-2-carboxamide
Purity >99% (HPLC); NMR (Conforms)
Biol. activity Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes. Not only does favipiravir inhibit replication of influenza A and B, but the drug has shown promise in the treatment of avian influenza, and may be an alternative option for influenza strains that are resistant to neuramidase inhibitors. Favipiravir has been investigated for the treatment of life-threatening pathogens such as Ebola virus, Lassa virus, and now COVID-19.
Applications Biochemical inhibition.
Appearance Dry, off-white powder.
Reconstitution Soluble in DMSO. May be dissolved in DMSO up to 30 mg/mL, or water up to 12 mg/mL.
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. Y Furuta et al. Antimicrob. Agents Chemother. 2002 46:977
2. K Takahashi et al. Antivir. Chem. Chemother. 2003 14:235
3. K Sleeman et al. Antimicrob. Agents Chemother. 2010 54:2517
4. Y Furuta et al. Antimicrob. Agents Chemother. 2005 49:981
5. Y Furuta et al. Antiviral Res. 2013 100:446
6. L Dong et al. Drug Discov.Ther. 2020 14:58
7. YF Tu et al. Int. J. Mol. Sci. 2020 21:E2657
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Favipiravir (5 mg)

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