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N4-Hydroxycytidine (25 mg)


Catalogue No. PE-1846-25
Description Pharmacology: N4-Hydroxycytidine was originally identified as a mutagen effecting AT to GC base-pair transitions (1). It has also been found to have antiviral properties against a broad range of viruses including hepatitis C (2), norovirus (3), Ebola virus (4), influenza and respiratory syncytial viruses (5) and coronaviruses (6). Active molecule in the antiviral pro-drug clinical candidate EIDD-28017. PubChem CID: 197020.

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.


InChI Key

Canonical SMILES

Isomeric SMILES
Batch No. See product label.
Unit size 25 mg
Other Names β-D-N4-hydroxycytidine; NHC; CAS 3258-02-4
Molecular Weight 259.2 g/mol. Molecular Formula: C9H13N3O6
Compound Name 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
Purity >98% (HPLC); NMR (Conforms)
Biol. activity Beta-d-N4-hydroxycytidine (NHC) is a nucleoside analogue that has antipestivirus and antihepacivirus activities; inhibits the production of cytopathic BVDV RNA with EC90 of 5.4 uM, also has an EC50 of 5 uM for replicon RNA reduction in Huh7 cells; also is a novel inhibitor of CHIKV (Chikungunya virus), inhibits venezuelan equine encephalitis virus (VEEV) with EC50 of <1 uM (8-11).
Applications Biochemical inhibition.
Appearance Dry, white powder.
Reconstitution Soluble in DMSO or slightly in water. May be dissolved in DMSO up to 25 mg/mL; water (15 mg/mL).
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. C Janion and BW Glickman Mutat. Res. 1980 72:43
2. LJ Stuyver et al. Antimicrob. Agents Chemother. 2003 47:244
3. VP Costantini et al. Antivir. Ther. 2012 1:981
4. O Reynard et al. Viruses 2015 7:6233
5. J-J Yoon et al. Antimicrob. Agents Chemother. 2018 62:e00766-18
6. K Pyrc et al. Antimicrob. Agents Chemother. 2006 50:2000
7. M Toots et al. Sci. Transl. Med. 2019 11:eaax5866
8. Stuyver LJ, et al. Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.
9. Barnard DL, et al. Antivir Chem Chemother. 2004 Jan;15(1):15-22.
10. Urakova N, et al. J Virol. 2017 Nov 22. pii: JVI.01965-17.
11. Ehteshami M, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02395-16.
MSDS Click to download the Material Safety Data SheetBiosensis SDS N4-Hydroxycytidine_4-30-2020.pdf
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N4-Hydroxycytidine (25 mg)

PDF Data Sheet

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