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Mouse polyclonal antibody to human Siah-1


Catalogue No. M-867-50
Description Siah-1 is a member of the seven in absentia homolog (SIAH) family. It is a E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including many proteins involved in transcription regulation, a cell surface receptor (DCC), cytoplasmic signal transduction molecules, an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP) and a structural protein. Consequently Siah-1 is involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis, and TNF-alpha signaling. It is predominantly a cytoplasmic protein but is also partially a nuclear protein. It is widely expressed at low levels and is down-regulated in advanced hepatocellular carcinomas.
Batch No. See product label
Unit size 50 uL
Antigen Partial recombinant human Siah-1 (amino acids 1-110) with a GST tag.
Other Names E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1a; SIAH1; HUMSIAH
Accession SIAH1_HUMAN
Produced in Mouse
Applications This antibody is recommended for ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Cross-reactivity Human. Other species have not been tested.
Blast it To see the shared identity between different species or other proteins, follow the link in the Accession field, select the sequence that you are interested in and copy and paste it HERE and blast/format it.
Form Liquid with 50% glycerol
Storage Keep aliquots at -20C for higher stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
PDF Data Sheet

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