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Nelfinavir Mesylate (25 mg)

$227.00USD


Catalogue No. PE-1848-25
Description Pharmacology: Nelfinavir is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM) (1). It also displays efficacy in cancer, malaria, tuberculosis and SARS (2). Displays broad spectrum anticancer activity and induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo (3). Inhibits the growth of HER2-positive breast cancer cells via inhibition of HSP90 through a novel mechanism (4). PubChem CID: 64142.

Product is sold for research use only, Not for human therapeutic use or for medicinal purposes.
Batch No. See product label.
Unit size 25 mg
Other Names Methanesulfonate; AG-1343; Nelfinavir; CAS 159989-65-8
Molecular Weight 663.9 g/mol. Molecular Formula: C32H45N3O4S • CH3SO3H
Compound Name (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide
Purity >98% (HPLC); NMR (Conforms)
Biol. activity Human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro (5).
Applications Biochemical inhibition.
Appearance Dry, white powder.
Reconstitution Soluble in DMSO. May be dissolved in DMSO up to 70 mg/mL.
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. M Olmo and D Podzamczer Expert Opin. Drug Metab. Toxicol. 2006 2:285.
2. A Brüning et al. Curr. Mol. Pharmacol. 2010 3:91.
3. JJ Gills et al. Clin. Cancer Res. 2007 13:5183.
4. JS Shim et al. J. Natl. Cancer Inst. 2012 104:1576.
5. Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.
MSDS Click to download the Material Safety Data SheetBiosensis SDS Nelfinavir mesylate 4-30-2020.pdf
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Nelfinavir Mesylate (25 mg)

PDF Data Sheet

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