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NGFR/p75ECD Rapid ELISA Kit: Human (2 Plates)


Catalogue No. BEK-2219-2P
  Find a 1 plate size of this product here. Enquire about bulk discounts for ten or more plates, at
This product is no longer available. Please see below for our recommended alternative products.
Replaced by BEK-2239-2P, Human NGFR/p75ECD RapidTM ELISA
Related products BEK-2220-2P, Mouse NGFR/p75ECD RapidTM ELISA

BL-002-1250, Heterophilic antibody blocker for ELISA assays utilizing mouse antibodies
Batch No. Refer to the product label.
Antigen The nerve growth factor (NGF) receptor (NGFR), also known as p75 neurotrophin receptor (p75NTR; TNFRS16; CD271) is a common receptor for the neurotrophins NGF, BDNF, NT-3 and NT-4/5. In neurons, p75NTR mediates a variety of physiological functions including survival, apoptosis, neurite outgrowth and synaptic plasticity. A potential pathological role for p75NTR has become evident in recent years. Altered p75NTR expression levels are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS). Importantly, the extracellular domain of p75NTR (p75ECD) is shed from the cell membrane and excreted in urine. Recent findings further suggest that p75ECD could be an early biomarker for ALS in humans, as significantly elevated p75ECD levels are found in urine of ALS patients as compared to healthy controls.
Other Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; Tumor necrosis factor receptor superfamily member 16; CD271; NGFR; TNFRSF16.
Accession TNR16_HUMAN
Specificity Human.
Cross-reactivity This ELISA kit does not cross-react with mouse p75ECD protein.
Storage Store at 2-8C.
Expiry Date 12 months from purchase.
References The following references give a general background on the suitability of p75ECD as a biomarker for ALS disease progression.

Shepheard et al. (2017) Neurology 2017 Feb 22. doi: 10.1212/WNL.0000000000003741. [Epub ahead of print].

Shepheard et al. (2014) PLoS ONE 9(1): e87398. doi:10.1371/journal.pone.0087398.

DiStefano & Johnson (1988) Proc Natl Acad Sci USA 85: 270-274.
Kit components The ELISA kit box contains 2 x 96-well pre-coated strip plates, protein standards, QC sample, detection reagents, heterophilic antibody blocker, wash and sample buffers, substrate buffer and detailed protocols.
Range 7.8 - 500 pg/mL
Sensitivity Typical limit of detection (LOD) for human p75ECD is less than 4 pg/mL, determined as concentration at blank OD plus 3x standard deviation of blank OD (n=10).
Kit protocol Click to download the kit protocolBEK-2219_as_at_Jun2018.pdf
MSDS Click to download the Material Safety Data SheetMSDS_Rapid_ELISA_as_at_Aug2017.pdf
Images (click to zoom)
NGFR/p75ECD Rapid ELISA Kit: Human (2 Plates) This standard curve generated in our laboratories is for demonstration purposes only, but can be used as a guide to expected performance. A standard curve should be generated for each assay.

PDF Data Sheet

Click to download the data sheet - Click to download the Data Sheet

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