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Nitazoxanide (50 mg)

$147.00USD


Catalogue No. PE-1850-50
Description Pharmacology: Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double- stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin (5). PubChem CID: 41684.

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.

InChI
InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChI Key
YQNQNVDNTFHQSW-UHFFFAOYSA-N

Canonical SMILES
CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
Batch No. See product label.
Unit size 50 mg
Other Names NTZ; CAS 55981-09-4
Molecular Weight 307.3 g/mol. Molecular Formula: C12H9N3O5S
Compound Name O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
Purity >98% (HPLC); NMR (Conforms)
Biol. activity NTZ demonstrates IC50 values of 2.5 and 10 uM for Giardia and Cryptosporidium, respectively. Additionally, NTZ kills replicating and nonreplicating M. tuberculosis with an IC50 value of 1 uM, while seemingly evading the development of resistance (6).
Applications Biochemical inhibition.
Appearance Dry, white powder.
Reconstitution Soluble in DMSO. May be dissolved in DMSO up to 50 mg/mL.
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. CA White Expert Rev. Anti. Infect. Ther. 2004 2:43
2. J-F Rossignol Antiviral Res. 2014 110:94
3. PS Hoffman et al. Antimicrob. Agents Chemother. 2007 51:868
4. M Elazar et al. Gastroenterology 2009 137:1827
5. Y Qu et al. Nat. Chem. Biol. 2018 14:94
6. de Carvalho., et al. 2009. J. Med. Chem. 52(19), 5789-5792
MSDS Click to download the Material Safety Data SheetBiosensis SDS Nitazoxanide_4-30-2020.pdf
Images (click to zoom)
Nitazoxanide (50 mg)

PDF Data Sheet

Click to download the data sheet - Click to download the Data Sheet

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