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Rabbit antibody to GFR alpha-2 (376-390): whole serum

$297.00USD


Catalogue No. R-067-100
Description FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; GPI-anchor (By similarity). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing.
Batch No. See product label
Unit size 100 uL
Antigen A synthetic peptide (PRVEKTPSLPDDLSD) as a part of human GFR alpha-2 protein (aa: 376-390) conjugated to KLH.
Sequence PRVEKTPSLPDDLSD
Antigen Location 376-390
Other Names GDNF family receptor alpha-2; GFR-alpha-2; Neurturin receptor alpha; NTNR-alpha; NRTNR-alpha; TGF-beta-related neurotrophic factor receptor 2; GDNF receptor beta; GDNFR-beta; RET ligand 2
Accession GFRA2_HUMAN
Produced in Rabbit
Purity Whole serum
Applications IHC, WB. A dilution of 1:500 to 1:1000 is recommended for both applications. This antibody stains beautifully the large neurons in the rat DRG. This antibody also is ideal for WB analysis of rat DRG and brain homogenate. The optimal dilution should be determined by the end user, but a dilution of 1 in 500 is recommended for initial testing. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity Western blot analysis indicates a high level of specificity to GFR alpha-2 for this antiserum.
Cross-reactivity This antibody is known to react with rat GFR alpha-2 and from IHC analysis, there appears to be no cross-reactivity with other members of the GFR family.
Blast it If you would like to use this product in another species other than those specified here, or to see the shared ID between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form Lyophilised
Reconstitution Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
References Rossi et al. (1999) Neuron. 22(2): 243
Klein et al. (1997) Nature. 387(6634): 717
Images (click to zoom)
Rabbit antibody to GFR alpha-2 (376-390): whole serum Immunohistochemical staining of rat dorsal root ganglia using Rabbit antibody to to GFR alpha-2 (376-390): whole serum, catalogue no. R-067-100.

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