||TISSUE SPECIFICITY: Predominantly expressed in trigeminal and dorsal root sensory ganglia. Isoform 1 and isoform 3 are also expressed in brain and peripheral blood mononuclear cells.
||See product label
||A synthetic peptide (YFSHLKEYVAS) of human capsaicin receptor protein (aa: 531-541) conjugated to KLH has been used as the immunogen.
||Transient receptor potential cation channel subfamily V member 1; TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; TRPV1; VR1; VR-1;
||IHC. Use at 1:1000 to 1:2000 dilution. This antibody has not been tested in other applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Immunohistochemical analysis of rat DRG indicates a superb degree of specificity for this serum.
||This antibody is known to react with rat Capsaicin and due to sequence homology is expected to react with mouse Capsaicin . Other species have not yet been tested.
||If you would like to use this product in another species other than those specified here, or to see the shared ID between the immunogen used here in different species and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
||Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
||After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent.
||12 months after purchase
||1. Rehman R et al (2013) TRPV1 inhibition attenuates IL-13 mediated asthma features in mice by reducing airway epithelial injury.
Int Immunopharmacol. 2013 Mar;15(3):597-605.
||1. Caterina et al. Nature 398: 436(1999).
2. Tominaga et al. Neuron. 21: 531-543(1998).
3. Nagy, I. et al. Eur J Pharmacol 500:351-369(2004).