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Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum

$297.00USD


Catalogue No. R-126-100
Description FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS); also called amyotrophic lateral sclerosis 1 (ALS1 or ALS). ALS is a degenerative disorder of motorneurons in the cortex, brainstem and spinal cord. ALS is characterized by muscular weakness and atrophy beginning in the hands and spreading to the forearms and legs. Muscle fasciculations are commonly visible. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as Lou Gehrig disease after the famous American baseball player who was diagnosed with the disorder. FALS, the familial form of ALS, accounts for about 10% of the cases and is transmitted in an autosomal dominant manner. The mean age at onset of FALS is 45 years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
Batch No. See product label
Unit size 100 uL
Antigen A synthetic peptide (ASGEPVV LSGQIT) as part of mouse superoxide dismutase (SOD1) protein (aa: 24-36) conjugated to diphtheria toxoid
Other Names Superoxide dismutase [Cu-Zn]; SOD1
Accession SODC_MOUSE
Produced in Rabbit
Purity Whole serum
Applications WB. A dilution of 1:500 to 1:1000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity Specificity was confirmed by western blot detecting mouse superoxide dismutase (SOD1).
Cross-reactivity This antiserum is known to react with mouse and rat superoxide dismutase (SOD1) protein.
Blast it If you would like to use this product in another species other than those specified here, or to see the shared ID between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form Lyophilised
Reconstitution Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Specific References Park KH et al. (2013) Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model. Nat Commun. 2013;4:2906.
General References 1. Jabusch J.R, et al. Biochemistry 19:2310-2316(1980).
2. Levanon D, et al. EMBO J. 4:77-84(1985).
3. Hallewell R.A, et al. Nucleic Acids Res. 13:2017-2034(1985).
4. Sherman L, et al. Proc. Natl. Acad. Sci. U.S.A. 80:5465-5469(1983).
5. Kajihara J, et al. J. Biochem. 104:851-854(1988).
6. Alexander M.D, et al. Ann. Neurol. 52:680-683(2002).
7. Gellera C, et al. Neuromuscul. Disord. 11:404-410(2001).
8. Murakami T, et al. J. Neurol. Sci. 189:45-47(2001).
9. Penco S, et al. Neurology 53:404-406(1999).
10. Morita M, et al. Neurosci. Lett. 205:79-82(1996).
11. Bartlett, et al. J. Neuroscience Methods. 98(1): 63-7(2000)
Images (click to zoom)
Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum Western blot detection of mouse SOD1 in mouse brain tissue extract (lane 1) when using Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum (catalogue no. R-126-100) at a dilution of 1:500. The immunoreactivity of this antibody is completely abolished when it is pre-incubated with the immunising SOD1 peptide (lane 2).

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MSDS

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